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. Author manuscript; available in PMC: 2011 Nov 1.
Published in final edited form as: Arch Environ Contam Toxicol. 2010 Apr 20;59(4):532–541. doi: 10.1007/s00244-010-9518-1

Table 4.

Relative potency ratios (A:Ba), ECx and slope dose-additivity quotient (AQ) and ECx independence quotient (IQ) values for each of the three halogenated acetonitriles tested in a binary mixture with a nonpolar narcotic using Microtox®

Mixture Time (min) A:B AQ–EC25 AQ–EC50 AQ–EC75 AQ-slope IQ–EC25 IQ–EC50 IQ–EC75
IAN–3M2Bb 15 1:3.72 0.95 1.16 1.44 0.80 0.93 1.17 1.23
30 1:1.73 1.00 1.22 1.49 0.81 0.97 1.10 1.47
45 1:1.11 1.15 1.30 1.47 0.87 1.07 1.21 1.56
BRAN–3M2B 15 1:3.62 1.04 1.21 1.41 0.85 1.00 1.04 1.20
30 1:1.65 1.09 1.27 1.52 0.85 1.02 1.13 1.44
45 1:0.98 1.08 1.30 1.56 0.81 0.98 1.21 1.68
CLAN–3M2B 15 1:1.94 0.87 1.09 1.39 0.78 0.78 0.96 1.32
30 1:0.92 1.04 1.23 1.46 0.83 0.92 1.16 1.60
45 1:0.63 1.07 1.30 1.58 0.80 0.96 1.27 1.84
a

Relative potency ratio of the first agent (A) to the second agent (B) in the mixture

b

IAN iodoacetonitrile, BRAN bromoacetonitrile, CLAN chloroacetonitrile, 3M2B 3-methyl-2-butanone