Comparison of growth factor expression profiles of hepatocellular carcinoma cells cultured in vitro for 10 days on different culture conditions. (a) IL-8, (b) bFGF, and (c) VEGF secretion by PCL and HepG2 cells cultured on 2D tissue culture plates, Matrigel matrices, and CA scaffolds as determined by ELISA. Results are mean ± s.d., and * indicates at least one of the means in that group is statistically different from the others, p < 0.05, n = 4.