. Author manuscript; available in PMC: 2011 Nov 15.

Published in final edited form as: Int J Cancer. 2010 Nov 15;127(10):2334–2350. doi: 10.1002/ijc.25222

Table 1.

Effects of oral BaP at 12.5 mg/kg/day for 12 weeks^*

Genotype	Clinical outcome	Number of mice in group	Number of mice with cancer
Cyp1(+/+)	Healthy	16	0
Cyp1a1(−/−)	Adenocarcinoma of PSI	16	13 (P <0.001)
Cyp1b1(−/−)	Healthy	16	0
Cyp1a1/1b1(−/−)	Squamous cell carcinoma of PGD	16	11 (P <0.001)^†

PSI, proximal small intestine; PGD, preputial gland duct. In these studies we did not include females, in which the clitoral gland is the equivalent of the preputial gland. Statistical values were calculated by chi-square analysis and Student’s two-tailed t-test.

^†

One mouse of this genotype showed a micro adenoma of the PSI that was found to express high IgG and IgM levels.