. Author manuscript; available in PMC: 2010 Aug 9.

Published in final edited form as: Ann Neurol. 2009 Jan;65(1):108–113. doi: 10.1002/ana.21576

Table 1.

Sequence Contexts Associated with Eukaryotic UGA Read-through

A. Sequence Contexts Associated with Eukaryotic UGA Read-through
Gene	Organism	Sequence
STE6⁷	S. cerevisiae	GGG CAA UGA CAA AGA
ADE2⁸	S. cerevisiae	ACC CAA UGA CAG UUA
Beta globin⁹	Oryctolagus cuniculus	UAC CAC UGA GAU CUU
ATP7A_R201X	H. sapiens	GUU CAG UGA AUU AAA

B. Sequence Contexts Associated with Other Nonsense Mutations in ATP7A
Gene	Mutation	Sequence

ATP7A	K155X	CUG GAG UAA AAG UCA
	Q168X	AUG GCU UAA GCU GGU
	R409X	UCC AUA UGA GUC UCC
	Y594X	AUC CUA UAG UGC UCC
	R645X	CAU AAA UGA GAA AUA
	R795X	CUA GGC UGA UGG CUG
	R980X	AUC UCC UGA ACA GAA
	Q1385X	GUU UUG UAG CCC UGG

All stop codons are shown in bold.

Conforming bases in the read-through sequence contexts are shown in red.