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. Author manuscript; available in PMC: 2010 Sep 20.
Published in final edited form as: Circulation. 2010 Apr 5;121(15):1735–1745. doi: 10.1161/CIRCULATIONAHA.109.899252

Figure 6.

Figure 6

In vivo proangiogenic effect of SVPs. A, Line graphs and representative laser Doppler images taken at day 7 from induction of unilateral limb ischemia (isch) illustrating the improvement of blood flow recovery in SVP-treated compared with vehicle-injected mice (arrow indicates time of cell injection; n=7 animals per group). Contra indicates contralateral. B and C, Bar graphs and representative pictures show increased capillary (B) and arteriole (C) density in muscles injected with SVPs compared with vehicle at 14 days after ischemia. Values are mean±SEM; n=4 animals per group.*P<0.05 vs vehicle; #P<0.05 and ##P<0.01 vs day 1. SVPs (DiI, red) persisted in ischemic muscle 14 days after injection (D), expressed human CD44 (E), and were positive for proliferating cell nuclear antigen (F; PCNA, arrowheads). Scale bar=20 μm. α-SMA indicates α-smooth muscle actin.