. 2010 Jun 9;95(8):3940–3948. doi: 10.1210/jc.2010-0025

Table 4.

Association of the nine SNPs with five pQCT traits in the ALSPAC cohort

Chromosomal region (gene) SNP (minor allele, frequency), sample size	BA_C (cm²)		BMC_C (mg)		BMD_C (mg/cm³)		CT (mm)		PC (mm)
	Model 1	Model 2	Model 1	Model 2	Model 1	Model 2	Model 1	Model 2	Model 1	Model 2
13q14 (RANKL)
rs9594738 (T, 0.489), n = 3093
β	−0.133	−0.34	−0.454	−0.692	−1.002	−1.022	−0.002	−0.003	0.002	−0.025
P	0.902	0.7	0.708	0.484	0.176	0.163	0.908	0.823	0.987	0.823
1p36
rs7524102 (G, 0.178), n = 3099
β	1.11	1.88	1.109	1.983	−0.817	−0.811	0.029	0.036	0.015	0.105
P	0.416	0.094	0.472	0.115	0.387	0.386	0.165	0.065	0.931	0.456
11q13 (LRP5)
rs3736228 (T, 0.153), n = 3087
β	−2.026	−0.776	−2.79	−1.373	−1.438	−1.308	−0.03	−0.017	−0.138	0.005
P	0.17	0.522	0.094	0.314	0.158	0.195	0.189	0.415	0.448	0.972
8q24 (OPG)
rs6993813 (T, 0.469), n = 3078
β	−0.251	0.253	0.094	0.67	1.201	1.295	0.015	0.02	−0.133	−0.073
P	0.816	0.775	0.939	0.501	0.107	0.079	0.354	0.2	0.318	0.514
rs4355801 (G, 0.457), n = 3084
β	−0.378	−0.35	0.004	0.039	1.431	1.39	0.016	0.016	−0.138	−0.133
P	0.722	0.689	0.997	0.968	0.051	0.055	0.331	0.302	0.294	0.226
18q21 (RANK)
rs3018362 (A, 0.349), n = 3093
β	0.442	0.044	−0.312	−0.762	−2.532	−2.534	−0.015	−0.019	0.244	0.2
P	0.692	0.961	0.804	0.459	0.001^b	0.001^b	0.369	0.226	0.076	0.083
6q25 (ESR1)
rs1038304 (A, 0.485), n = 3076
β	−1.042	−0.572	−0.628	−0.099	1.444	1.459	−0.01	−0.005	−0.133	−0.082
P	0.322	0.509	0.597	0.919	0.048^a	0.043^a	0.544	0.756	0.308	0.453
17q21 (SOST)
rs1513670 (T, 0.363), n = 3082
β	−0.171	0.412	−0.227	0.446	−0.13	0.034	−0.004	0	−0.017	0.059
P	0.879	0.656	0.859	0.668	0.868	0.965	0.81	0.99	0.904	0.614
14q32 (MARK3)
rs2010281 (A, 0.347), n = 3096
β	1.745	0.503	2.581	1.165	2.122	1.85	0.03	0.02	0.098	−0.054
P	0.116	0.581	0.039^a	0.255	0.006^a	0.015^a	0.073	0.219	0.477	0.64

Model 1 is adjusted for age and sex. Model 2 is adjusted for age, sex, height, and weight (ln). β-Coefficients represent the increase (positive values) or decrease (negative values) in the trait per addition of minor allele. SNPs are ordered by effect size as reported by the Genetic Factors of Osteoporosis Consortium (8) or Ref. 6 for rs3018362.

P < 0.05.

P < 0.0021.