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Relationship of stroke, traumatic brain injury, and diverse stressors to delirium. Schematic demonstration of potential pathophysiologic pathways linking stroke, traumatic brain injury and environmental, medical stressors with delirium. Ach = acetylcholine; ChAT = choline acetyltransferase; IGF-1 = insulin-like growth factor 1; CNS = central nervous system. *Represents one potential pathophysiologic pathway to delirium; other mechanisms exist.
