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. Author manuscript; available in PMC: 2010 Aug 9.
Published in final edited form as: Chem Biol Drug Des. 2008 Jul 15;72(2):111–119. doi: 10.1111/j.1747-0285.2008.00687.x

Table 1.

OBOC library design. The key features of YJ34 were constrained in the library. The library had the Gly at position 5, the Cys at positions 3 and 7 with a disulfide bonds, and a C-terminal amide. The other 5 amino acid positions were randomized such that each bead had only one sequence. Half of the peptides on each bead had an acetyl group and the other half had a free N-terminus. There were 300 pmoles peptide on each bead, 2.5 million sequences and 7.9 million beads in the library.

Name Sequence Bridge
Gαi switch I …Val-Lys-Thr-Thr-Gly-Ile-Val-Glu… none
YJ34 Ac-Val-Lys-[Cys-Thr-Gly-Ile-Cys]-Glu-NH2 (S-S)
Library graphic file with name nihms223845t1.jpg (S-S)