. Author manuscript; available in PMC: 2011 Jun 1.

Published in final edited form as: Drug Alcohol Depend. 2010 Jan 15;109(1-3):130–138. doi: 10.1016/j.drugalcdep.2009.12.018

Table 2.

Mean peak subjective effects ± one standard error of the mean for non-drug abusers and drug abusers as a function of oxycodone dose (VAS range: 0–100 mm; DEQ range: 0–4, except for drug liking, which ranged from −4 to 4; OSC range: 0–13) Items shown are those for which statistically significant changes were found.

	Non-drug Abusers			Drug Abusers
	0 mg/70 kg	15 mg/70 kg	30 mg/70 kg	0 mg/70 kg	15 mg/70 kg	30 mg/70 kg
Visual Analog Scales
Bad Effect	4.2 (1.6)	26.8 (7.8) ^a	46.8 (7.6) ^a, ^b	14.7 (6.3)	29.8 (7.1)	43.1 (8.1) ^a
Good Effect	13.8 (3.9)	55.7 (7.9) ^a	51.2 (9.2) ^a	21.7 (5.8)	66.3 (6.5) ^a	64.0 (6.6) ^a
High	8.4 (3.6)	61.9 (8.5) ^a	65.2 (7.9) ^a	24.1 (6.8)	68.7 (5.2) ^a	76.4 (6.3) ^a
Liked the Choice	21.4 (6.9)	53.6 (8.1) ^a	40.6 (9.1)	23.0 (5.2)	59.6 (6.8) ^a	58.8 (7.8) ^a
Nauseated	9.7 (4.1)	25.9 (7.4)	41.6 (9.2) ^a	10.6 (6.4)	38.1 (9.4) ^a	44.4 (9.9) ^a
Potent	9.3 (5.8)	63.3 (8.2) ^a	61.4 (9.9) ^a	22.3 (6.6)	64.6 (6.8) ^a	82.3 (6.3) ^a
Quality	13.0 (6.2)	55.2 (9.4) ^a	45.0 (9.9)	18 (4.8)	61.9 (6.6) ^a	62.8 (7.6) ^a
Sleepy	44.3 (8.7)	72.2 (7.0) ^a	68.8 (8.2) ^a	52.1 (8.5)	68.1 (8.5)	71.5 (7.6)
Social	24.9 (5.7)	27.7 (4.6)	28.9 (6.3)	22.4 (5.7)	45.4 (6.5) ^a	41.9 (7.1) ^a
Stimulated	44.6 (5.3)	54.0 (7.3)	51.4 (7.3)	23.6 (5.2)	54.8 (7.8) ^a	52.9 (8.6) ^a
Talkative	18.4 (6.0)	29.5 (5.8)	26.1 (6.3)	21.3 (5.0)	48.9 (6.3) ^a	42.4 (6.3) ^a
Would Pay ($)	0.28 (0.28)	2.28 (0.73)	2.11 (0.68)	1.50 (0.65)	6.89 (1.02) ^a	7.39 (1.40) ^a

Drug Effects Questionnaire
Bad Effect	0.2 (0.1)	1.6 (0.3) ^a	2.1 (0.3) ^a	0.3 (0.1)	1.1 (0.3)	1.7 (0.3) ^a
Good Effect	0.8 (0.2)	2.6 (0.3) ^a	2.8 (0.3) ^a	1.2 (0.2)	3.0 (0.2) ^a	2.8 (0.3) ^a
Like	0.8 (0.3)	2.3 (0.3) ^a	2.2 (0.3) ^a	1.1 (0.3)	2.8 (0.2) ^a	2.6 (0.3) ^a
Strong	1.4 (0.3)	3.2 (0.2) ^a	3.5 (0.2) ^a	1.7 (0.3)	3.4 (0.1) ^a	3.7 (0.2) ^a
Take Again	2.6 (0.4)	3.3 (0.2)	3.2 (0.2)	1.7 (0.3)	3.1 (0.3) ^a	3.0 (0.3) ^a

Opiate Symptom Checklist
Sum	3.2 (0.4)	5.8 (0.4) ^a	6.8 (0.4) ^a	2.9 (0.4)	6.6 (0.5) ^a	7.2 (0.5) ^a

indicates a significant difference from placebo and

indicates a significant difference between 15 and 30 mg/70 kg oxycodone.