Table 3.
Univariate lod scores > 2.07 (suggestive) for linkage to lipid levels. At the same location, P-values for the QTL effects (q22) for T2D, BMI, and WHR and for pleiotropy (ρq) between the QTL effects of the lipid and T2D, BMI, and WHR from bivariate linkage analysis.
Chromosome | Position (MB)1 | Lipid | Lod2 | P-Value3 | |||||
---|---|---|---|---|---|---|---|---|---|
T2D | BMI | WHR | |||||||
q22 | ρq | q22 | ρq | q22 | ρq | ||||
1 | 202–209 | TG | 2.97 | 0.364 | 0.751 | 0.0150 | 0.0301 | 0.128 | 0.257 |
4 | 99–113 | TG | 2.35 | 0.0572 | 0.439 | 1.00 | 1.00 | 0.444 | 0.887 |
5 | 12–32 | HDL-C | 2.49 | 0.113 | 0.225 | 0.149 | 0.298 | 0.0265 | 0.0541 |
5 | 29–32 | TG | 2.72 | 0.0766 | 0.153 | 1.00 | 1.00 | 0.0688 | 0.138 |
7 | 147–151 | TG | 3.08 | 0.0203 | 0.0407 | 0.143 | 0.353 | 0.0496 | 0.117 |
10 | 87–108 | LDL-C | 2.29 | 0.0776 | 0.155 | 0.0160 | 0.0560 | 0.450 | 0.901 |
19 | 29–38 | TC | 2.13 | 0.349 | 0.698 | 0.213 | 0.975 | 0.290 | 0.581 |
20 | 20–38 | TG | 3.57 | 0.0192 | 0.886 | 0.0624 | 0.469 | 0.104 | 0.560 |
1-lod drop support interval in megabases, Build 37.1
Significant (>3.29, bold) and near-significant (>3.00, italics) univariate lod scores.
For q22, Significant (<0.0167, bold) and near-significant (<0.0333, italics) P-values. For ρq, significant (<0.05, bold) and near-significant (<0.1, italics) P-values.