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. Author manuscript; available in PMC: 2011 Feb 1.
Published in final edited form as: Nature. 2010 Aug 5;466(7307):774–778. doi: 10.1038/nature09301

Figure 2. Acetyl groups deriving from glucose and glutamine are functionally distinct.

Figure 2

a, Labeling of acetyl-CoA in extracts of P. falciparum-infected RBCs at t = 40 hpi as determined by HPLC-MS. b, Labeling of a singly-acetylated peptide derived from the N-terminal tail of histone H4, determined by proteomic MS. c, Labeling of UDP-GlcNAc at t = 40 hpi. Black bars: unlabeled molecule; red bars: the molecule labeled at both carbons of the acetyl group, regardless of any other labeling; dark gray bars: acetyl-CoA labeled at all 5 carbons of the ribose moiety of CoA, but not the acetyl group; white bars: UDP-GlcNAc labeled at some combination of the glucose, ribose or pyrimidine ring, but not the acetyl group; light gray bars: UDP-GlcNAc labeled at 1–3 nitrogens, but at no carbons. Error bars show the s.d. of n = 3 biological replicates.