Skip to main content
. Author manuscript; available in PMC: 2011 Feb 1.
Published in final edited form as: Nature. 2010 Aug 5;466(7307):774–778. doi: 10.1038/nature09301

Figure 4. An integrated model for central carbon metabolism in P. falciparum.

Figure 4

Arrows show direction of net flux; multiple arrows depict pathways not shown in their entirety and are labeled as such. Metabolites in red are those found to be effluxed into the medium as waste products. The red arrows indicate the reductive pathway of TCA metabolism, while the blue arrows show the oxidative pathway. Asterisk (*): the specific enzyme responsible for the citrate cleavage step and its localization are unclear (see text). Double asterisk (**): there are two predicted enzymes capable of catalyzing this reaction, the cytosolic malate dehydrogenase (PFF0895w) and the putative mitochondrial malate:quinone oxidoreductase (MAL6P1.258). Abbreviations: Gln, glutamine; Glu, glutamate; OG, 2-oxoglutarate; ICT, isocitrate; Cit, citrate; Ac-R, acetate/acetyl-CoA; Ac-CoA, acetyl-CoA; OA, oxaloacetate; Mal, malate; Suc-CoA, succinyl-CoA; Fum, fumarate; Glc, glucose; Asp, aspartate; PEP, phosphoenolpyruvate; Pyr, pyruvate; Lac, lactate.