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. 2010 Aug;78(2):186–197. doi: 10.1124/mol.109.062216

Fig. 4.

Fig. 4.

Direct PKC activation enhances HERG protein abundance. Immunoblot analysis of HEK cells stably expressing HERG in response to PMA treatment. A, shows changes in HERG with increasing duration of treatment with PMA at 10 nM. B, shows changes in HERG with increasing concentration of PMA treatment for 24 h. C, two PKC inhibitors, bisindolylmaleimide I and Ro 32-0432, block the PMA-dependent increase in HERG protein. D, a comparison of α1A-AR receptor stimulation (PE) is made with direct PKC activation (PMA) (n = 3; ∗, p < 0.05; ∗∗, p < 0.025; ∗∗∗, p < 0.01).