TABLE 1.

Comparison of kinetic parameters and inhibition potency data between CID 16725315 and CID 23631927

	Thiocarbazate CID 16725315	Oxocarbazate CID 23631927
k1	3.09 × 106 M−1·s−1	2.27 × 106 M−1·s−1
k−1	0.32 s−1	0.29 s−1
kcat	4.31 s−1	3.78 s−1
kon	3.27 × 104 M−1·s−1	1.53 × 105 M−1·s−1
koff	3.75 × 10−5 s−1	4.40 × 10−5 s−1
Ki = koff/kon	1.15 nM	0.29 nM
Human Cat L. IC50
0 h	56 ± 4 nM	6.9 ± 1.0 nM
4 h	1.0 ± 0.5 nM	0.4 ± 0.1 nM
SARS IC50		273 ± 49 nM
Ebola IC50		193 ± 39 nM
Inhibition of intracellular Cat L.	2%	38%
Cat L/B Selectivity	40–50	735