Fig. 7.

CDDO-Me inhibits pancreatic tumor growth and down-regulates Sp proteins and Sp dependent genes. Tumor weights (A) and volume (B). Male athymic nude mice bearing orthotopic pancreatic (L3.6pL) tumors were treated with corn oil or CDDO-Me (7.5 mg/kg) for 4 weeks, and tumor weights and tumor volumes (in cubic millimeters) were determined as described under Materials and Methods. Significant (P < 0.05) inhibition (*) is indicated in results as means ± S.E. for five animals per treatment. Western blot analysis of tumor lysates for Sp proteins (C) and Sp-dependent proteins (D). Lysates from three mice in the treated and control groups were analyzed by Western blots as described under Materials and Methods. β-Actin served as loading control.