. Author manuscript; available in PMC: 2011 Jul 12.

Published in final edited form as: J Comb Chem. 2010 Jul 12;12(4):566–570. doi: 10.1021/cc100054u

Table 1.

Screening of reaction conditions for the solid-phase Ugi multi-component reaction

Entry	Reagents (equiv.)			time (h)	Temp (°C)	yield (%) ^a
Entry	PS Glu	BnNC	Cyclohexanone	time (h)	Temp (°C)	yield (%) ^a
4a	1	1.1	1.1	24	65	58
4b	1	1.5	1.5	24	65	75
4c	1	2	2	24	65	83
4d	1	2	2	12	65	66
4e	1	2	2	24	25	51

Yields based on the weight of purified product and are relative to the initial loading of the resin. The purity of the purified compounds is higher than 95% for all the compounds. The purity was estimated on analytical traces at λ= 214 nm and 254 nm.