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. Author manuscript; available in PMC: 2011 Jul 12.
Published in final edited form as: J Comb Chem. 2010 Jul 12;12(4):566–570. doi: 10.1021/cc100054u

Table 2.

Synthesis of substituted pyrrolidinones.

graphic file with name nihms212294u1.jpg
Entry R1 Y X Obtained MW Yield (%)a
5a graphic file with name nihms212294t1.jpg -NBoc- -NH- 345 (MH+) 80
5b graphic file with name nihms212294t2.jpg -CH2- -CH2- 336 (MH+) 82
5c graphic file with name nihms212294t3.jpg -CH2- -CH2- 310 (MH+) 78
5d graphic file with name nihms212294t4.jpg -CH2- -CH2- 367 (MH+) 70
a

Yields based on the weight of purified product and are relative to the initial loading of the resin. The purity of the purified compounds is higher than 95% for all the compounds. The purity was estimated on analytical traces at λ= 214 nm and 254 nm.