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. Author manuscript; available in PMC: 2011 Aug 1.
Published in final edited form as: Neurotox Res. 2009 Oct 23;18(2):200–209. doi: 10.1007/s12640-009-9124-z

Figure 2.

Figure 2

Upper panels: Dihydroxyphenylacetic acid (DOPAC)/dopamine ratio in striatum of mdr1a +/+ and mdr1a −/− mice 0.3 to 4 h after 10, 20 or 40 mg/kg MDMA i.p. (n=5 for each time-point). Lower panels: DOPAC/dopamine ratio in striatum of mdr1a +/+ and mdr1a −/− mice 24 h after 10, 20 or 40 mg/kg MDMA i.p. (n=5 for each time-point). Data are expressed as mean percent of saline control ± 95% confidence intervals. Control mice were sacrificed one h after saline administration i.p. (n=5). Post hoc comparisons for inter-strain differences: *differs from corresponding dose and time point in mdr1a −/− mice and # differs from corresponding dose and time point in mdr1a +/+ mice (p<0.0006). Post hoc comparisons for intra-strain differences: adiffers from saline control; bdiffers from 10mg/kg; cdiffers from 20mg/kg; and ddiffers from 40mg/kg MDMA (p<0.0006).