Table 2.
List of phosphoproteins whose level of expression was altered by at least 1.5-fold are listed by inhibition of Cyclin D1-cdk4/6 activity using p16INK4a peptides in MDA-MB-231 cells.
| Gene Symbol | Name | GenBank Accession No. |
Fold Change (p16Ink4 peptide vs. no peptide) |
Associatio n with cancer |
|---|---|---|---|---|
| c11orf30 | EMSY(chromosome 11 ORF 30) | Q7Z589 | 2.3 | × |
| CALU | Calumenin precursor(Crocalbin) | O43852 | 2.9 | × |
| EEF1B2 | eukaryotic translation elongation factor 1 beta 2 | P24534 | 2.4 | × |
| EIF5 | eukaryotic translation initiation factor 5 | P55010 | 2.8 | × |
| ENO1 | enolase 1, (alpha) | P06733 | 2.4 | × |
| ERBB2IP | erbb2 interacting protein | Q96RT1 | 2.6 | × |
| FAM120A | family with sequence similarity 120A | Q9NZB2 | 2.4 | |
| GATA4 | GATA binding protein 4 | P43694 | 2.8 | × |
| HSPB1 | heat shock 27kDa protein 1 | P04792 | 2.2 | × |
| ITIH2 | inter-alpha(globulin) inhibitor H2 | P19823 | 2.5 | × |
| ITSN2 | intersectin2(ITSN2, SH3P18) | Q9NZM3 | 2.3 | |
| KRT1 | Keratin 1 (epidermolytic hyperkeratosis, CK1) | P04264 | 2.1 | × |
| KRT10 | keratin 10(epidermolytic hyperkeratosis) | P13645 | 2.2 | × |
| LAMB2 | laminin, beta 2(laminin S) | P55268 | 7.9 | × |
| LASP1 | LIM and SH3 Protein 1 | Q14847 | 2.9 | × |
| LRIT1 | Leucine-rich repeat-containing protein21 precusor(LRC21) | Q9P2V4 | 2.2 | |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | P29966 | 2.2 | × |
| MLL | myloid/lymphoid or mixed lineage leukimia | Q03164 | 2.7 | × |
| MYO7A | myosin VIIA | Q13402 | 2.1 | |
| NOL1 | nucleolar protein 1, 120 kDa | P46087 | 2.5 | × |
| PCYT1A | phosphate cytidylyltranferase 1, choline, alpha | P49585 | 2.3 | |
| PCYT1B | phosphate cytidylyltranferase 1, choline, beta | Q9Y5K3 | 2.1 | |
| PDLIM4 | PDZ and LIM domain 4 | P50479 | 2 | × |
| PKP4 | Plakophilin-4 | Q99569 | 2.5 | × |
| PPFIA2 | Liprin-alpha-2(LIPA2, PTPRF-interacting protein alpha-2) | Q75334 | 2.4 | × |
| PRSS1 | protease, serine, 1(trypsin 1) | Q07477 | 3.7 | × |
| RCN1 | Reticulocalbin-1 precusor | Q15293 | 2.5 | × |
| RHPN2 | rhophilin-like protein | Q8IUC4 | 10.1 | |
| RPL10 | 60S ribosomal protein L10 | P27635 | 2.4 | × |
| RPL13 | ribosomal protein L13 | P26373 | 3.6 | × |
| RPL27A | ribosomal protein L27a | P46776 | 2.2 | × |
| RPS6 | 40S ribosomal protein S6 | P62753 | 2 | × |
| SEC22A | vesicle-trafficking protein SEC22a | Q96IW7 | 3 | |
| SEC61B | protein transport protein Sec61 beta subunit | P60468 | 2.1 | |
| TALDO1 | transaldolase 1 | P37837 | 6.3 | × |
| TPI1 | triosephosphate isomerase 1 | P60174 | 1.7 | |
| TUBA1B | tubulin, alpha_ubiquitous chain | P68363 | 2.1 | |
| TUBA1C | tubulin, alpha 6 | Q9BQE3 | 3.1 | |
| TUBB1 | tubulin, beta 1 | P07436 | 2.3 | × |
| TUBB5 | tubulin, beta 5 | Q7JJU6 | 2.4 | × |
| TUFM | Tu translation elongation factor, mitochondrial (EFTU) | P49411 | 2.4 | |
| VPS13D | vacuolar protein sorting-associated protein 13D | Q5THJ4 | 3.3 | |
| YLPM1 | YLP motif-containing protein 1(YLPM1, ZAP113) | P49750 | 2.6 | |
| ZNF148 | Zinc finger protein 148 | Q9UQR1 | 3.2 | × |
| AFAP1 | actin filament associated protein | Q8N556 | −3.3 | |
| AHI1 | Abelson helper integration site 1 protein homolog(AHI-1 ,Jouberin) | Q8N157 | −2.2 | × |
| AHNAK | AHNAK nucleoprotein isoform 1 | Q09666 | −2.5 | |
| ARHGEF2 | rho/rac guanine nucleotide exchange factor 2 | Q9H023 | −2.7 | × |
| BCLAF1 | BCL2-associated transcription factor 1 | Q9NYF8 | untreated only | |
| C11orf58 | small acidic protein | O00193 | −7.1 | |
| CLIC6 | chloride intracellular channel 6 | Q96NY7 | untreated only | |
| CST4 | Cystatin-S precusor | P01036 | −2.1 | |
| DYNC1LI1 | dynein light chain-A | Q9Y6G9 | −2.2 | |
| EHA2 | ephrin receptor EphA2 | P29317 | untreated only | × |
| ERRFI1 | mitogen-inducible gene 6 protein | Q9UJM3 | −2.6 | × |
| FAM129B | Hypothetical protein LOC64855 | Q5VVW7 | −5.3 | |
| FAM82C | family with sequence similarity 82, member C | Q96TC7 | untreated only | |
| FLNA | filamin 1(actin binding protein-280) | P21333 | −1.5 | × |
| G3BP1 | Ras-GTPase-activiting protein SH3-domain-binding protein | Q13283 | −3.7 | × |
| HN1 | hematological and neurological expressed 1 isoform 1 | Q9UK76 | −6.7 | × |
| HRNR | Hornerin | Q86YZ3 | −2.9 | × |
| MACF1 | microtubule-actin crosslinking factor 1 | Q96PK2 | −2.1 | × |
| NCOA3 | nuclear receptor coactivator 3 | Q9Y6Q9 | −2.1 | × |
| NOP5/NOP58 | nucleolar protein NOP5/NOP58 | Q9Y2X3 | −2.8 | × |