Table 1.
Cross-reactive class 1–restricted viral T-cell epitopesa
| Virus/epitope | Sequence | Reference |
|---|---|---|
| Mouse | ||
| LCMV NP205 (Kb): | Y T V K Y P N L | (50, 51) |
| PV NP205 (Kb): | Y T V K F P N M | |
| VVa11r198 (Kb) | A I V N Y A N L | (12, 156) |
| LCMV NP205 (Kb): | Y T V K Y P N L | |
| PV NP205 (Kb): | Y T V K F P N M | |
| LCMV GP118(Kb): | I S H N F C N L | |
| LCMV GP34(Kb): | A V Y N F A T C | |
| VV e7r130 (Kb) | S T L N F N N L | |
| IAV PA224 (Db) | S S L E N F R A Y V | Wlodarczyk & Selinb |
| LCMV GP276 (Db) | S G V E N P G G Y C L | |
| IAV PB1703(Kb) | S S Y R R P V G I | Wlodarczyk & Selinb |
| LCMV GP34(Kb) | A V Y N F A T C | |
| IAV NP147 (Kd): | T Y Q R T R A L V R T G | (42) |
| IAV PB2146 (Kd): | V F P N E V G A R I L T S E | |
| IAV PB2185 (Kd): | E R E L V R K T R | |
| RSV M282 (Kd): | S Y I G S I N N I | (157) |
| RSV M271 (Kd): | E Y A L G V V G V | |
| IAV HA515 (Kd): | ILAIYSTVASSL | (158) |
| IAV NS150 (Kd): | LGLDIETATRAGKQIVERI | |
| IAV NP366 (Db): | A S N E N M D A M | (55) |
| IAV NP366 variant (Db): | A S N E N M E T M | |
| Dengue 2 NS3298 (Kd): | G Y I S T R V E M | (159) |
| Dengue 3 NS3299 (Kd): | G Y I S T R V G M | |
| Dengue 1 E331 (Ld) | A P C K I P F S S | (160) |
| Dengue 2 E331 (Ld) | S P C K I P F E I | |
| Dengue 3 E331(Ld) | A P C K I P F S T | |
| Dengue 4 E331(Ld) | A P C K V P I E I | |
| Sin nombre virus N331(Kb): | F A I L Q D M R N T I | (161) |
| Puumala virus N331(Kb) | F S I L Q D M R N T I | |
| Hanta virus N331(Kb) | F S I L Q D M R N T I | |
| VV-WR F2L26 (Ld) | S P Y A A G Y D L | (162) |
| MVA F2L26 (Ld) | S P G A A G Y D L | |
| Ectomelia (ECTV) F2L26 (Ld) | S N H A A G Y D L | |
| Human | ||
| EBV BMLF1280 (A2): | G L C T LV A M L | (58) |
| IAV A M158 (A2): | G I L G F V F T L | |
| EBV BRLF1 (A2): | Y V L D H L I V V | cornberg& selinb |
| EBV LMP2329(A2): | L L W T L V V L L | |
| IAV NP85(A2): | K L G E F Y N Q M M | |
| IAV NA231 (A2): | C V N G S C F T V | (68, 119) |
| HCV NS31073 (A2): | C V N G V C W T V | |
| IAV M158 (A2): | G I L G F V F T L | (163) |
| HIV-1P17 GAG77(A2): | S L Y N T I A V L | |
| HPV16 E711 (A2): | Y M L D L Q P E T | (164) |
| Coronavirus NS252 (A2): | T M L D I Q P E D | |
| HIVenvgp120 (A2): | V P T D P N P P E V | (164) |
| M. tuberculosis 19 kDa (A2): | V L T D G N P P E V | |
| Rotavirus VP486(A2): | CPTNQQVVLEGTNKTD | (165) |
| IAV M155 (A2): | LTKGILGFVFTLTVPSERG | |
| Dengue 2 NS371 (B62) | D V K K D L I S Y | (166) |
| Dengue 3 NS371 (B62) | S V K K D L I S Y | |
| Dengue 1 NS3133 (A11) | G T S G S P I V N R | (49) |
| Dengue 2 NS3133 (A11) | G T S G S P I I D K | |
| Dengue 3/4 NS3133 (A11) | G T S G S P I I N R | |
| Dengue 1 NS4b111 (A2) | V L M L V A H Y A | (167) |
| Dengue 2 NS4b111 (A2) | F L L V A H Y A I | |
| Dengue 3 NS4b111 (A2) | V L L L V T H Y A | |
| Dengue 3 NS4b111 (A2) | L V M L L V H Y A | |
| Dengue 1 NS4b181 (A2) | I L L M R T T W A | (167) |
| Dengue 2 NS4b181 (A2) | V L L M R T T W A | |
| Dengue 3 NS4b181 (A2) | L L L M R T S W A | |
| Dengue 4 NS4b181 (A2) | L L L M R T T W A | |
| Dengue 1 NS4a56 (A2) | M L L A L I A V L | (167) |
| Dengue 2 NS4a56 (A2) | L L L T L L A T V | |
| Dengue 3 NS4a56 (A2) | L L L G L M I L L | |
| Dengue 4 NS4a56 (A2) | M L V A L L G A M | |
| Dengue 1 E211 (A2) | F L D L P L P W T | (167) |
| Dengue 2 E211 (A2) | F L D L P L P W L | |
| Dengue 3 E211 (A2) | F F D L P L P W T | |
| Dengue 4 E211 (A2) | F F D L P L P W L | |
| Hantavirus Sin Nombre | I S N Q E P L K L | (168) |
| N421 (A1): | ||
| Hantavirus Seoul virus N421 (A1): | I S N Q E P M K L | |
a
This table lists the virus, viral protein, epitope number, and class I MHC-restricted element for mouse (top) and human (bottom) cross-reactive CD8 T cell epitopes. With paired epitopes the amino acids in common are underlined. With clusters of epitopes the amino acid in common with the top bolded epitope are underlined. Within clusters of epitopes there may also be T cell cross-reactivity within subsets of the epitopes.
*
Unpublished epitope data from L.K. Selin and coworkers.