Figure 3.

Serial evaluation of the change in the daily PELOD (Pediatric Logistic Organ Dysfunction) score from day 1, adjusted for baseline value (PELOD score on day 1). *Hazard ratio (HR) of death and 95% confidence interval (CI) are reported per point increase in the change in score. The cumulative HR of death was calculated as follows: (HR of PELOD score on day 1) × (HR of change in score from day 1 to specified day). For example, for a child whose score is 23 on day 1 and 13 on day 5, the change in score is −10; the HR for death would be 21.48 [61.55 × (1.11⁻¹⁰) = 61.55 × 0.35]. For a child whose score is 12 on day 1 and 32 on day 16, the change in score is 20; in this instance, the HR for death would be 98.37 [6.12 × (1.15²⁰) = 6.12 × 16.08].