Table 2.
Risk of serious liver disease in association with newly diagnosed diabetes mellitus in 2 497 777 study participants
| Study outcome | Study group; no. (incidence rate per 10 000 person-years) |
HR (95% CI)* |
||
|---|---|---|---|---|
| Newly diagnosed diabetes mellitus n = 438 069 | No diabetes mellitus n = 2 059 708 | Unadjusted | Adjusted† | |
| Primary: any serious liver disease | 2 463 (8.19) | 5 902 (4.17) | 1.92 (1.83–2.01) | 1.77 (1.68–1.86) |
| Secondary | ||||
| Liver cirrhosis | 1 119 (3.71) | 1 896 (1.34) | 2.71 (2.51–2.92) | 2.55 (2.35–2.76) |
| Liver failure and its sequelae | 1 760 (5.84) | 4 485 (3.16) | 1.80 (1.70–1.91) | 1.69 (1.59–1.79) |
| Liver transplantation | 174 (0.58) | 449 (0.32) | 1.80 (1.51–2.15) | 1.31 (1.05–1.64) |
CI = confidence interval, HR = hazard ratio.
*
Comparison of those with newly diagnosed diabetes mellitus and matched individuals without diabetes mellitus.
†
Adjusted for age (continuous, in years); income quintile; urban residence; presence of arterial hypertension, dyslipidemia, obesity or cardiovascular disease within 36 months before study entry; number of hospital admissions within 36 months before study entry; and number of primary care visits within 12 months before study entry.