Fig. 3. As in Figure 2A, but for conjugates at residues 153 (A), 239 (B), 602 (C), 711 (D), 713 (E) and 745 (F). Conjugate positions are labeled and highlighted in magenta on the polymerase structures, and cleavage positions (for the +15 and +19 complexes) are in yellow and green for the template and non-template strand, respectively. Note that, with the exception of the structure in (C), DNA extensions have been modeled onto the EC structure to allow display of cleavage positions lying up- or downstream of the visible DNA in the EC crystal structure.