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. 2003 Dec 15;22(24):6430–6437. doi: 10.1093/emboj/cdg629

graphic file with name cdg629f3.jpg

Fig. 3. Effect of dominant-negative sortilin lacking its cytoplasmic domain in COS-7 cells immunostained with anti-GM2AP antibody. COS-7 cells were immunostained with anti-GM2AP antibody following a transfection with truncated sortilin (A). COS-7 cells were also stained for the truncated sortilin construct (B). The merged image shows GM2AP in a perinuclear staining pattern in the same compartment as the truncated sortilin construct (C). Immunostaining for endogenous GM2AP demonstrates its normal distribution in non-transfected COS-7 cells (D). Scale bar = 20 µm.