Table 2.
Testing for Significance of Linkage Disequilibrium between the Putative Major Gene and the p53 Gene
| Maximum-Likelihood Estimate (Standard Error) | |||
|---|---|---|---|
| Parameter | Male without LD | Model with LD | |
| Baseline Risk λk (10−5): | |||
| Age Group | 0 – 15 | 6.60 | 9.70 |
| 15 – 30 | 25.88 | 37.96 | |
| 30 – 45 | 64.80 | 94.58 | |
| 45 – 60 | 152.17 | 213.51 | |
| 60 –75 | 596.74 | 704.22 | |
| p53 Major Gene: γ(g=Aa, AA) | 4.06 (0.41) | 3.69 (0.40) | |
| Relative Risk (=exp(γ)) | 57.97 | 40.04 | |
| qA | 2.84×10−2(1.55×10−2) | 4.66×10−3(3.20×10−4) | |
| qB | 6.25×10−14(0.00) | 1.22×10−10(3.20×10−4) | |
| qAB | N. A. | 1.22×10−10(3.20×10−4) | |
| Lindage Analysis | |||
| Highest LOD-scpre | 17.74 | 21.21 | |
| θ̂p53 | 0.00 | 0.00 | |
| −2 Log-Likelihood: | 878.67 | 865.46 | |
| Likelihood Ratio Test (LRT): | |||
| Degree of freedom | 1 | ||
| χ2 value | 13.21 | ||
| P-value | 2.78×10−4 | ||
The parameter λk represents the estimates of the baseline annual age-specific cancer incidence rate per 100,000 persons for age groups of 0–15, 15–30, 30–45, 45–60, and 60–75 years, respectively.