Table 3.

Outcomes of Complex Joint Segregation and Linkage Analyses

		Covariates Included in the Models
	Parameter	No Covariate	Male	Male×p53	Male + Male×p53
Baseline Risk λk (10−5):
Age Group	0 – 15	9.70	13.41	9.63	8.81
	15 – 30	37.96	52.87	38.07	34.85
	30 – 45	94.58	143.85	107.48	98.30
	45 – 60	213.51	337.00	260.58	238.58
	60 –75	704.22	863.72	649.62	598.16
p53 Major Gene: γ(g=Aa, AA)		3.69 (0.40)	3.67 (0.37)	4.09 (0.41)	4.18 (0.52)
Relative Risk (=exp(γ))		40.04	39.25	59.74	65.37
		4.66 × 10−3	1.76 × 10−4	1.09 × 10−3	1.85 × 10−3
	qA	( 3.20 × 10−4 )	(2.62 × 10−5 )	(2.16 × 10−4 )	(1.66 × 10−5 )
		1.22 × 10−10	2.13 × 10−11	1.75 × 10−10	1.15 × 10−11
	qB	(3.20 × 10−4 )	(5.01 × 10−5 )	(3.29 × 10−4 )	(1.91 × 10−5 )
		1.22 × 10−10	2.13 × 10−11	1.75 × 10−10	1.15 × 10−11
	qAB	(3.20 × 10−4 )	(5.01 × 10−5 )	(3.29 × 10−4 )	(1.91 × 10−5 )
Covariate z
	Male		−0.65 (0.31)		0.15 (0.59)
	Male×p53			−0.88 (0.32)	−1.02 (0.66)
−2 Log-Likelihood:		865.46	861.10	858.99	858.96
AIC:		887.46	885.10	882.99	884.96
Likelihood Ratio Test (LRT):
Degree of freedom			1	1	1
	χ2		4.36	6.47	0.03
	P-value		3.68 × 10−2	1.01 × 10−2	0.86

Male is coded as 0 for females and 1 for males. The values of θ̂_p53 = 0.0 and D' ≈ 1 are across the models of Table 3.