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. Author manuscript; available in PMC: 2010 Aug 9.

Published in final edited form as: Virology. 2009 May 13;389(1-2):100–107. doi: 10.1016/j.virol.2009.03.029

HPV16 DNA methylation patterns A, B and C

The panels show three HPV16 methylation patterns: A, B and C, respectively. The x-axis is the same for all panels, but only the CpGs with methylation in each pattern are labeled. The nucleotide numbers are those of the W12 isolate of HPV16 (Flores et al., 1999) (Genbank AF125673). The bars represent CpGs that were methylated in only one sample per pattern (□); only two samples (patterns A and B) or two to four samples (pattern C) (grey ), and all five samples of pattern C (■). One sample in pattern A was missing data at position 1509, and one in pattern C, at position 4247. Not shown are the 52 unmethylated CpGs. The y-axis shows the mean percentage of HPV16 genomes per sample with methylation at each CpG plus the S.E.M.

Inline graphic — HPV16 DNA methylation patterns A, B and C

The panels show three HPV16 methylation patterns: A, B and C, respectively. The x-axis is the same for all panels, but only the CpGs with methylation in each pattern are labeled. The nucleotide numbers are those of the W12 isolate of HPV16 (Flores et al., 1999) (Genbank AF125673). The bars represent CpGs that were methylated in only one sample per pattern (□); only two samples (patterns A and B) or two to four samples (pattern C) (grey ), and all five samples of pattern C (■). One sample in pattern A was missing data at position 1509, and one in pattern C, at position 4247. Not shown are the 52 unmethylated CpGs. The y-axis shows the mean percentage of HPV16 genomes per sample with methylation at each CpG plus the S.E.M.