Figure 6.
A model for the role and regulation of PfPI3K in malaria parasite. PfPI3K is trafficked to vesicular compartments at PM/PVM and the food vacuole, and exported to the host RBCs. It may regulate the function of FCP, a PI3P binding protein, which is present in the food vacuole.8 PfPI3K inhibition blocks endocytosis of hemoglobin to the food vacuole and blocks parasite growth. Because PfPI3K exported to the host erythrocyte is active, it may trigger signaling and trafficking pathways that may regulate additional events.