TABLE. PD Imaging Studies of Striatal or Putaminal Dopaminergic Deficits at Time of Symptom Onset.
| AUTHOR | YEAR | N | MODALITY | LIGAND | STRIATUM (% LOSS) | PUTAMEN (% LOSS) | ANALYSIS |
|---|---|---|---|---|---|---|---|
| LEVODOPA METABOLISM | |||||||
| Morrish et al | 1995 | 11 | PET | [18F]DOPA | --- | 20-43 | HY I (IPSI vs CONTRA) |
| Morrish et al | 1998 | 32 | PET | [18F]DOPA | --- | 25 | REGRESSION |
| Lee et al | 2000 | 13 (HY I) | PET | [18F]DOPA | --- | 38-52 | HY I (IPSI vs CONTRA) |
| Hilker et al | 2005 | 31 | PET | [18F]DOPA | --- | 31 | REGRESSION |
| DOPAMINE TRANSPORTER BINDING | |||||||
| Tissingh et al | 1998 | 8 (HY I) | SPECT | [123I]β-CIT | 39-51 | 51-64 | HY I (IPSI vs CONTRA) |
| Lee et al | 2000 | 13 (HY I) | PET | [11C]MP | --- | 56-71 | HY I (IPSI vs CONTRA) |
| Schwartz et al | 2004 | 6 | SPECT | [123I]IPT | 43 | 56 | REGRESSION |
| VESICULAR MONOAMINE TRANSPORTER BINDING | |||||||
| Lee et al | 2000 | 13 (HY I) | PET | [11C]DTBZ | 51-62 | HY I (IPSI vs CONTRA) | |
In each study, the degree of dopaminergic terminal loss in whole striatum or putamen was determined either by regression analysis with back extrapolation to Time = 0, or by determination of the loss on the side ipsilateral (IPSI) to symptoms in comparison to the side contralateral (CONTRA) to symptoms in patients with unilateral PD (Hoehn and Yahr Stage I (HY I)). β-CIT: 2β-carbomethoxy-3 β -(4-iodophenyl); MP: methylphenidate; IPT: N-(3-iodopropene-2-yl)-2β - carbomethoxy-3β -(chlorophenyl); DTBZ: dihydrotetrabenazine.