Table 3.
Rest-Activity Rhythms and Risk of All-Cause and Cause-Specific Mortality
| HR* (95% CI) | |||||
|---|---|---|---|---|---|
| All-Cause (N=2945) |
CVD (n= 78) |
Cancer (n=75) |
Other (n=80) |
||
| Acrophase | |||||
| 8.74–13.37 | 53 (9) | 1.16 (0.77–1.74) | 2.84 (1.29–6.24) | 0.65 (0.32–1.32) | 0.97 (0.47–2.01) |
| 13.37–13.98 | 39 (7) | 0.86 (0.56–1.33) | 1.40 (0.58–3.40) | 0.57 (0.28–1.16) | 0.99 (0.48–2.05) |
| 13.98–14.53 | 45 (8) | 1.0 | 1.0 | 1.0 | 1.0 |
| 14.53–15.15 | 44 (7) | 0.99 (0.65–1.50) | 1.76 (0.76–4.07) | 0.68 (0.34–1.36) | 0.97 (0.47–2.03) |
| 15.15–24.4 | 52 (9) | 1.04 (0.69–1.57) | 1.55 (0.67–3.60) | 0.82 (0.42–1.61) | 1.18 (0.59–2.35) |
| p-value | 0.707 | 0.061 | 0.553 | 0.976 | |
| Amplitude | |||||
| <2732 | 84 (14) | 1.25 (0.82–1.90) | 1.27 (0.61–2.65) | 1.23 (0.57–2.67) | 1.24 (0.62–2.47) |
| 2732–3316 | 39 (7) | 0.77 (0.49–1.23) | 0.92 (0.42–2.05) | 0.85 (0.38–1.91) | 0.60 (0.27–1.34) |
| 3316–3780 | 44 (7) | 0.98 (0.63–1.53) | 0.95 (0.42–2.15) | 1.30 (0.62–2.73) | 0.78 (0.36–1.71) |
| 3780–4362 | 30 (5) | 0.75 (0.46–1.22) | 0.57 (0.22–1.49) | 1.22 (0.57–2.58) | 0.47 (0.19–1.20) |
| ≥4362 | 36 (6) | 1.0 | 1.0 | 1.0 | 1.0 |
| P-trend | 0.187 | 0.226 | 0.963 | 0.244 | |
| Mesor | |||||
| <1790 | 69 (12) | 1.04 (0.69–1.55) | 0.80 (0.41–1.57) | 0.98 (0.45–2.13) | 1.23 (0.61–2.47) |
| 1791–2030 | 47 (8) | 0.90 (0.59–1.37) | 0.65 (0.32–1.35) | 1.07 (0.50–2.26) | 1.05 (0.51–2.18) |
| 2030–2235 | 38 (6) | 0.79 (0.51–1.23) | 0.56 (0.26–1.23) | 1.22 (0.59–2.53) | 0.64 (0.28–1.48) |
| 2235–2500 | 36 (6) | 0.71 (0.45–1.11) | 0.56 (0.26–1.21) | 1.17 (0.56–2.45) | 0.41 (0.16–1.04) |
| ≥2500 | 43 (7) | 1.0 | 1.0 | 1.0 | 1.0 |
| P-trend | 0.394 | 0.841 | 0.854 | 0.057 | |
| Pseudo F-value | |||||
| <640 | 82 (14) | 1.57 (1.03–2.39) | 2.32 (1.04–5.22) | 0.90 (0.42–1.90) | 1.95 (0.94–4.05) |
| 640–854 | 58 (10) | 1.38 (0.89–2.12) | 1.76 (0.76–4.10) | 1.22 (0.62–2.42) | 1.44 (0.67–3.08) |
| 854–1093 | 28 (5) | 0.73 (0.44–1.20) | 1.19 (0.48–2.96) | 0.66 (0.30–1.45) | 0.45 (0.17–1.23) |
| 1093–1416 | 31 (5) | 0.88 (0.54–1.43) | 0.86 (0.31–2.37) | 0.80 (0.38–1.69) | 1.07 (0.46–2.49) |
| ≥1416 | 34 (6) | 1.0 | 1.0 | 1.0 | 1.0 |
| Ptrend | 0.003 | 0.006 | 0.755 | 0.024 | |
| Beta | |||||
| <4.4 | 52 (9) | 1.39 (0.94–2.06) | 1.82 (0.90–3.69) | 1.06 (0.55–2.05) | 1.49 (0.75–2.98) |
| 4.4–6.8 | 37 (6) | 1.06 (0.69–1.64) | 1.58 (0.75–3.31) | 0.43 (0.18–1.04) | 1.53 (0.75–3.10) |
| 6.8–12.0 | 44 (7) | 1.19 (0.79–1.79) | 1.46 (0.70–3.05) | 0.86 (0.43–1.74) | 1.46 (0.72–2.95) |
| 12.0–26.2 | 41 (7) | 0.93 (0.62–1.40) | 1.23 (0.61–2.50) | 0.86 (0.45–1.67) | 0.76 (0.35–1.65) |
| ≥26.2 | 59 (10) | 1.0 | 1.0 | 1.0 | 1.0 |
| P-trend | 0.088 | 0.077 | 0.680 | 0.872 | |
| Alpha | |||||
| <−0.50 | 55 (9) | 1.42 (0.93–2.18) | 0.81 (0.36–1.83) | 3.37 (1.51–7.52) | 0.98 (0.48–2.01) |
| −0.50,−0.40 | 38 (6) | 1.13 (0.71–1.79) | 0.99 (0.44–2.25) | 1.72 (0.71–4.16) | 0.96 (0.46–2.03) |
| −0.40,−0.29 | 36 (6) | 1.0 | 1.0 | 1.0 | 1.0 |
| −0.29,−0.12 | 44 (7) | 1.19 (0.76–1.86) | 1.21 (0.57–2.56) | 1.75 (0.72–4.26) | 0.87 (0.41–1.84) |
| −0.12,1.00 | 60 (10) | 1.52 (1.00–2.31) | 1.65 (0.83–3.28) | 1.94 (0.82–4.59) | 1.20 (0.61–2.37) |
| P-trend | 0.661 | 0.038 | 0.081 | 0.655 | |
*
Adjusted for age, age2, site, race, alcohol, caffeine use, self-reported health status, IADL impairments, cardiovascular disease, diabetes, cognitive impairment, depressive symptoms and self-reported kidney disease.