Figure 2. The role of SDF-1α-CXCR4 pathway in tumor re-growth after local irradiation.
A, Representative fluorescence confocal microscopy images of tumor immunostaining for SDF-1α and quantification of SDF-1α expression before and 2 days after 20Gy of radiation. Irradiation induced a significant increase in SDF-1α. B,C, Effect of CXCR4 blockade using AMD3100 on tumor re-growth after irradiation of 54A (B) and MCa8 (C) tumors. CXCR4 blockade delayed tumor growth when commenced immediately after but not 5 days after irradiation (n=6-8). (*denotes p<0.05).