Skip to main content
. Author manuscript; available in PMC: 2010 Aug 9.
Published in final edited form as: Nat Med. 2005 Jun 12;11(7):791–796. doi: 10.1038/nm1268

Figure 5. In vivo.

Figure 5

infectivity of JFH1 virus produced In tissue culture. Chimpanzee X0215 was first inoculated with 1 ml of the undiluted culture medium from mock-transfected Huh7 cells (Ctrl). We re-inoculated the chimpanzee 6 weeks later with 1 ml of a 104 dilution of culture medium from full-length JFH1 RNA-transfected cells (104). After 6 more weeks, we repeated inoculatlon with 1 ml of a 103 dilution (103). The course of infection is shown with arrows indicating the three inoculations. HCV RNA (copies/ml) and ALT (IU/L) levels are plotted; HCV-specific, HCV RNA and liver biopsy results are shown above the graph.