Fig. 6.

Troglitazone and fenofibrate are similar to mitochondrial inhibitors in inducing more toxicity in MM versus B-cell leukemia lines which associates with increases in CHOP/GADD153 expression. Cytotoxicity was measured by trypan blue exclusion assays following 24 h of treatment with either a fenofibrate or b troglitazone. The graph demonstrates the average of triplicate samples + SD. c Induction of UPR-mediated apoptosis by troglitazone and fenofibrate was assayed by western blot analysis of CHOP/GADD153 and cleaved caspase 3 levels