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. 2010 Sep;51(9):2766–2774. doi: 10.1194/jlr.M008359

Fig. 3.

Fig. 3.

A schematic overview of association analyses for 16 SNPs in the FADS gene cluster and PUFAs (N = 10) and PUFA ratios (N = 5) in 224 subjects from the Tangier population. The ratios included are (i) enzymatic activity in the total pathway in ω6 series (TPω6) defined as (AA+ADA)/(LA+GLA+DHGLA); (ii) enzymatic activity in the total pathway in ω3 series (TPω3) defined as (EPA+DPA)/(ALA+SDA+ETEA); (iii) Fatty acid desaturase 1 (FADS1) activity in the ω6 series (FADS1ω6) defined as (AA+ADA)/DHGLA; (iv) FADS1 activity in the ω3 series (FADS1ω3) defined as (EPA+DPA)/ETEA; and (v) FADS2 activity in the ω6 series (GLA/LA). The P values of these association tests are shown in Panel A, and the specific allele associated with an increased mean trait value for each phenotype is shown in Panel B for all tests, where P < 0.05. Color key mapping P values and alleles to specific color codes are displayed. Abbreviations: AA, arachidonic acid; ADA, adrenic acid; ALA, alpha-linolenic acid; DHGLA, dihomo-gamma-linolenic acid; DPA, docosapentaenoic acid; EPA, eicosapentanoic acid; ETEA, eicosatetraenoic acid; FADS, fatty acid desaturase; GLA, gamma-linolenic acid; LA, linoleic acid; PUFA, polyunsaturated fatty acid; SNP, single nucleotide polymorphism.