Figure 1 Spinal muscular atrophy–lower extremity, dominant pedigree and haplotype analysis

Gender and birth order have been deidentified to protect family privacy. Filled diamonds denote affected individuals while open diamonds represent unaffected individuals. A slash indicates deceased individuals. Generations are labeled with roman numerals while individuals are identified by numeral. The disease-associated haplotype is shaded in gray. The proband is marked with a large arrow. The small arrow and arrowhead mark recombination events that narrow the overall locus. Inferred haplotypes are indicated in italics. Eleven descendants of IV-1 are affected by family reports but were not available for study.