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Genome-wide type I error and power for δ12 from a mixture distribution for various sample sizes with genome-wide significance 0.05
| β1 = 0; Size | β1 =.25; Power | |||||
|---|---|---|---|---|---|---|
| n0=n1 | 1,000 | 5,000 | 10,000 | 1,000 | 5,000 | 10,000 |
| Control only, WCO | 0.049 | 0.049 | 0.049 | 0.000 | 0.060 | 0.504 |
| Adaptively weighted, WAW | 0.049 | 0.049 | 0.049 | 0.002 | 0.500 | 0.982 |
| Case only, WCA | 1.000 | 1.000 | 1.000 | 0.001 | 0.064 | 0.505 |
| Weighted, WW | 1.000 | 1.000 | 1.000 | 0.002 | 0.504 | 0.984 |
| MLE, WMLE | 1.000 | 1.000 | 1.000 | 0.002 | 0.504 | 0.984 |
