Table 3.

Inhibition constants of anionic inhibitors against various CAs

Inhibitor			KI [mM]#
	HCA II	Nce103	ScCA	CgCA	DmBCA
F-	>300	0.69	2.85	0.36	0.80
Cl-	200	0.85	0.85	0.58	0.97
Br-	63	0.94	0.0108	27	1.04
I-	26	1.40	0.0103	42.4	1.18
CNO-	0.03	1.18	31.7	0.60	0.73
SCN-	1.6	0.65	55.6	0.73	1.28
CN-	0.02	0.011	16.8	1.12	0.67
N3-	1.5	0.52	27.9	1.03	1.12
HCO3-	85	0.62	0.78	0.086	26.9
NO3-	35	0.69	13.9	0.097	43.7
NO2-	63	0.53	0.46	0.088	28.6
HS-	0.04	0.37	0.33	0.10	1.01
HSO3-	89	0.54	0.33	0.10	1.29
SO42-	>200	14.15	0.58	0.58	1.36
ClO4-	>200	>200	>200	>200	>200
H2NSO2NH2	1.13	0.30	0.0087	0.42	0.15
H2NSO3H§	0.39	0.70	0.84	0.11	2.45
Ph-B(OH)2	23.1	30.8	38.2	0.10	22.4
Ph-AsO3H2§	49.2	30.8	0.40	0.098	32.6

Inhibition constants against isozymes HCA II (α-CA class), and the β-CAs Nce103 (from C. albicans), ScCA (from S. cerevisiae), CgCA (from C. glabrata) and DmBCA (D. melanogaster) for the CO₂ hydration reaction at 20°C are shown.

^§As sodium salt.

^# Errors in the range of 5-10% of the shown data, from three different assays, by a CO2 hydration stopped-flow assay.