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. 2010 Jul 22;7:34. doi: 10.1186/1476-9255-7-34

Figure 4.

Figure 4

Airspace enlargement and lung mechanical properties in ApoE-/- mice exposed to CS. Representative figure of H&E stained lung sections from air- and CS-exposed WT and ApoE-/- mice (A). Arrows indicate alveolar enlargement. Mean linear intercept (Lm) was calculated in H&E stained lung sections. Original magnification: ×200. Histogram represents (B) mean ± SEM (n = 3-4 mice per group). **P < 0.01, significant compared with corresponding air-exposed mice. ++P < 0.01, significant compared with CS-exposed WT mice. ##P < 0.01, significant compared with air-exposed WT mice. Lung compliance (C) and resistance (D) were measured in air- and CS-exposed WT and ApoE-/- mice using Flexivent. Data are shown as mean ± SEM (n = 3-4 mice per group). **P < 0.01, significant compared with corresponding air-exposed mice. +++P < 0.001, significant compared with CS-exposed WT mice. #P < 0.05, ###P < 0.001, significant compared with air-exposed WT mice.