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. 2003 Dec 15;31(24):7099–7109. doi: 10.1093/nar/gkg924

Figure 5.

Figure 5

Reconstruction of known biochemical pathways and protein complexes in M.tuberculosis. Panels (A), (C), (E) and (G) each depict the clustering pattern of a subset of genes of our hierarchical clustered functional linkage map. Panels (B), (D), (F) and (H) represent known biochemical pathways and known protein complexes. (A) All nine genes of the histidine biosynthesis pathway are clustered together, along with the hisC2 paralog, yielding complete enumeration of the catalytic elements of the histidine biosynthesis pathway. (B) Histidine biosynthesis pathway. (C) All seven genes of the arginine biosynthesis pathway cluster together, giving a complete enumeration of the arginine biosynthesis enzymes. (D) Arginine biosynthesis pathway. (E) Seven of the eight genes involved in the mycobacterial ATP synthase complex cluster together. (F) ATP synthase multiprotein complex. (G) All three proteins of the bacterial cytochrome c oxidase complex cluster together along with the cytochrome c oxidase assembly factor, ctaB. (H) Cytochrome c oxidase.