Table 1. Half-life values of the glycosylic bond stability of 2′-deoxyisoguanosine derivatives.
Compound | τ (min) | Conditions | τ (min) | Conditions |
---|---|---|---|---|
iGda | 8 | 0.1 M HCl, rt | ||
4 | 12.5 | 0.5 M HCl, rt | <2 | 0.5 M HCl, 40°C |
5 | 10 | 0.5 N HCl, 60°C | 46 | 0.5 N HCl, 40°C |
6 | 14 | 0.5 N HCl, 60°C | 52 | 0.5 N HCl, 40°C |
aSeela and Gabler (24).