TABLE 2.
Odds ratios and 95% confidence intervals between body weight and physical activity on colorectal adenomas, hyperplastic polyps, and both lesions.
| Characteristic | Controls | Adenomas | Hyperplastic Polyps | Both | |||
|---|---|---|---|---|---|---|---|
| N (%) | N (%) | OR (95% CI)* | N (%) | OR (95% CI)* | N (%) | OR (95% CI)* | |
| Current BMI (kg/m2)‡ | |||||||
| 18.5–24.9 | 319 (41%) | 170 (33%) | 1.00 (Referent) | 277 (40%) | 1.00 (Referent) | 68 (30%) | 1.00 (Referent) |
| 25–29.9 | 293 (38%) | 202 (39%) | 1.21 (0.92–1.58) | 263 (38%) | 1.02 (0.80–1.31) | 82 (36%) | 1.08 (0.74–1.59) |
| ≥30 | 158 (21%) | 143 (28%) | 1.65 (1.22–2.25) | 148 (22%) | 1.09 (0.81–1.45) | 76 (34%) | 2.15 (1.43–3.22) |
| p-trend | 0.002 | 0.6 | 0.0003 | ||||
| BMI (kg/m2) age 18‡ | |||||||
| <18.5 | 87 (11%) | 62 (12%) | 1.23 (0.86–1.77) | 73 (11%) | 0.95 (0.67–1.35) | 18 (8%) | 0.84 (0.47–1.50) |
| 18.5–24.9 | 603 (79%) | 377 (73%) | 1.00 (Referent) | 536 (78%) | 1.00 (Referent) | 160 (71%) | 1.00 (Referent) |
| 25–29.9 | 72 (9%) | 58 (11%) | 1.21 (0.83–1.77) | 69 (10%) | 1.05 (0.73–1.50) | 43 (19%) | 1.99 (1.28–3.09) |
| ≥30 | 6 (1%) | 16 (3%) | 4.02 (1.55–10.50) | 8 (1%) | 1.35 (0.46–3.97) | 5 (2%) | 3.02 (0.89–10.28) |
| p-trend | 0.2 | 0.6 | 0.002 | ||||
| Weight Gain from age 18‡ | |||||||
| Weight Loss | 51 (7%) | 28 (5%) | 1.03 (0.60–1.78) | 46 (7%) | 1.26 (0.78–2.03) | 10 (4%) | 1.22 (0.54–2.74) |
| 0–5 kg | 150 (20%) | 80 (16%) | 1.00 (Referent) | 108 (16%) | 1.00 (Referent) | 25 (11%) | 1.00 (Referent) |
| 6–10 | 124 (16%) | 86 (17%) | 1.23 (0.83–1.82) | 123 (18%) | 1.37 (0.96–1.96) | 32 (14%) | 1.34 (0.74–2.44) |
| 11–20 | 245 (32%) | 165 (32%) | 1.18 (0.84–1.66) | 229 (33%) | 1.28 (0.94–1.75) | 85 (38%) | 1.90 (1.15–3.14) |
| 21+ | 196 (26%) | 153 (30%) | 1.41 (0.99–2.02) | 178 (26%) | 1.29 (0.93–1.80) | 73 (32%) | 2.16 (1.28–3.63) |
| Physical activity¶ | |||||||
| Never | 476 (62%) | 352 (68%) | 1.00 (Referent) | 424 (61%) | 1.00 (Referent) | 152 (67%) | 1.00 (Referent) |
| Ever | 296 (38%) | 167 (32%) | 0.78(0.61–1.00) | 267 (39%) | 1.02 (0.81–1.27) | 75 (33%) | 0.88 (0.63–1.24) |
| Total minutes of exercise (per week)¶ | |||||||
| No exercise | 476 (62%) | 352 (68%) | 1.00 (Referent) | 424 (61%) | 1.00 (Referent) | 152 (67%) | 1.00 (Referent) |
| <45 | 67 (9%) | 36 (7%) | 0.73 (0.47–1.13) | 55 (8%) | 0.89 (0.60–1.32) | 18 (8%) | 0.84 (0.47–1.50) |
| 45–89 | 79 (10%) | 51 (10%) | 0.90 (0.61–1.33) | 78 (11%) | 1.11 (0.78–1.57) | 16 (7%) | 0.64 (0.35–1.19) |
| 90–119 | 56 (7%) | 26 (5%) | 0.66 (0.40–1.09) | 46 (7%) | 0.94 (0.62–1.44) | 15 (7%) | 1.12 (0.60–2.09) |
| ≥120 | 94 (12%) | 54 (10%) | 0.79 (0.55–1.15) | 87 (13%) | 1.07 (0.77–1.49) | 26 (11%) | 0.99 (0.60–1.63) |
*
Adjusted for age, sex, race, education, smoking, alcohol, NSAID use, and family history of colorectal cancer, and menopausal status and hormone use in women
‡
Additional adjusted for physical activity
¶
Additionally adjusted for body mass index and diabetes