. Author manuscript; available in PMC: 2011 Aug 1.

Published in final edited form as: Growth Horm IGF Res. 2010 May 26;20(4):305–309. doi: 10.1016/j.ghir.2010.04.001

TABLE 3.

Odds ratios and 95% confidence intervals between genotypes of IGF-1 and receptor, IGFBP-3, and growth hormone with colorectal adenomas, hyperplastic polyps and both lesions.

Characteristic	Controls	Adenomas		Hyperplastic Polyps		Both
Characteristic	N (%)	N (%)	OR (95% CI)^*	N (%)	OR (95% CI)^*	N (%)	OR (95% CI)^*
Total
IGF-1 (rs5742612)
AA	523 (88%)	363 (91%)	1.00 (Referent)	483 (93%)	1.00 (Referent)	155 (90%)	1.00 (Referent)
GA/GG	69 (12%)	37 (9%)	0.78 (0.50–1.19)	37 (7%)	0.57 (0.37–0.87)	17 (10%)	0.85 (0.48–1.51)
IGF-1 receptor (rs2229765)
GG	197 (33%)	132 (33%)	1.00 (Referent)	160 (31%)	1.00 (Referent)	55(32%)	1.00 (Referent)
GA	286 (49%)	183 (46%)	0.99 (0.74–1.32)	260 (50%)	1.15 (0.88–1.51)	75(44%)	0.99 (0.66–1.47)
AA	106 (18%)	80 (20%)	1.17 (0.81–1.69)	101 (19%)	1.21 (0.86–1.71)	40(24%)	1.42 (0.88–2.30)
IGFBP3 (rs2854746)
GG	193 (32%)	143 (36%)	1.00 (Referent)	203 (39%)	1.00 (Referent)	62(36%)	1.00 (Referent)
CG	308 (52%)	197 (49%)	0.87 (0.66–1.15)	234 (44%)	0.73 (0.56–0.94)	85(49%)	0.87 (0.60–1.26)
CC	93 (16%)	58 (15%)	0.83 (0.56–1.23)	89 (17%)	0.91 (0.64–1.29)	25(15%)	0.82 (0.48–1.40)
Growth hormone (rs2665802)
AA	195 (34%)	150 (38%)	1.00 (Referent)	200 (39%)	1.00 (Referent)	69(41%)	1.00 (Referent)
AT	280 (48%)	191 (49%)	0.89 (0.67–1.18)	244 (47%)	0.85 (0.65–1.10)	72(42%)	0.73 (0.50–1.07)
TT	106 (18%)	51 (13%)	0.63 (0.42–0.94)	74 (14%)	0.68 (0.48–0.98)	29(17%)	0.79 (0.48–1.29)

Adjusted for age, sex, and race