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. Author manuscript; available in PMC: 2011 Sep 15.
Published in final edited form as: Neuroscience. 2010 Jun 19;169(4):1848–1859. doi: 10.1016/j.neuroscience.2010.05.052

Figure 7.

Figure 7

Representative MEA tracings from a rat receiving an intracortical perfusion of kynurenine (2.5 μM, 45 min duration). The self-referenced glutamate signal (Self Ref) shows a kynurenine-induced decline in glutamate that begins within 6 min of the start of the perfusion, reaches a maximal decrease of 1.7 μM (25% decrease from baseline), and persists for 5 ½ hrs.