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Representative MEA tracings from a rat receiving an intracortical perfusion of the KAT II inhibitor S-ESBA (5 mM, 45 min duration). The bottom trace illustrates the self-referenced glutamate signal (Self Ref) and reveals a S-ESBA-induced increase in glutamate levels, which is apparent 5 min after the start of the perfusion. The increase reaches a maximum of 2.1 μM (37% above baseline) and persists for approximately 1 hr.
