TABLE 1.
GLUTAMATE LEVELS FOLLOWING SYSTEMIC INJECTIONS: GROUP MICROELECTRODE DATA
| MEASURE | KYNURENINE (25 mg/kg) | KYNURENINE (50 mg/kg) | GALANTAMINE (3 mg/kg) + KYNURENINE (50 mg/kg) |
|---|---|---|---|
| BASAL GLUTAMATE (μM) | 6.0 ± 1.3 | 6.2 ± 1.4 | 6.5 ± 1.6 |
| POST-INJECTION GLUTAMATE (% CHANGE FROM BASAL) | 5.4 ± 1.2 ( −10.6 ±1.1a) | 4.4 ± 1.1 (−30.8 ± 5.0) | 5.7 ± 1.4 (−10.8 ± 2.3a) |
| TIME TO EFFECT (min) | 16.2 ± 4.9 | 5.4 ± 3.6 | 16.3 ± 8.9 |
| TIME TO MAX EFFECT (min) | 111.2 ± 23.3a | 314.0 ± 20.0 | 77.8 ± 20.2a |
| DURATION OF EFFECT (min) | 210.3 ± 21.6a | > 6 hr | 146.6 ± 13.4a,b |
All pharmacological treatments were administered via intraperitoneal (i.p.) injections. Values are means ± S.E.M. with n = 5 rats/treatment group.
a
= significantly different from kynurenine (50 mg/kg)
b
= significantly different from kynurenine (25 mg/kg)