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. Author manuscript; available in PMC: 2010 Aug 10.

Published in final edited form as: Kidney Int. 1999 Jan;55(1):294–298. doi: 10.1046/j.1523-1755.1999.00237.x

Table 2.

Effects of ibuprofen on the kidney during water diuresis in young subjects

	Antidiuresis						Diuresis

	R₂* medulla	R₂* cortex	PGE₂ excretion pg/min	V ml/min	U_Osm mOsm/kg	C_Cr ml/min	R₂* medulla	R₂* cortex	PGE₂ excretion pg/min	V ml/min	U_Osm mOsm/kg
No ibuprofen (6)	17.9 ± 0.45	11.9 ± 0.4	237 ± 62	0.44 ± 0.12	839 ± 80	116 ± 16	13.2^a ± 0.56	11.4 ± 0.35	478^a ± 21	11.1^a ± 0.9	55^a ± 4
Ibuprofen (6)	18.45 ± 0.71	12.13 ± 0.34	213 ± 44	0.49 ± 0.14	846 ± 113	121 ± 16	17.6^b ± 0.36	11.2 ± 0.28	89^a ^b ± 11	9.1 ± 0.7	64 ± 6.4

^a

Significantly different from antidiuresis, (P < 0.01)

^b

Significantly different from no ibuprofen, (P < 0.01)