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Primary Reason for Study Exclusion
| After relevance screen | |
| Review/letter/editorial | 384 |
| Nonrandomized/nontreatment study | 20 |
| Wrong focus or population | 1244 |
| After full manuscript review | |
| Review article | 1 |
| Duplicate publication | 4 |
| Not critically ill | 16 |
| Wrong outcome | 18 |
| Wrong treatment | 5 |
| Wrong focus or population | 3 |
| Manuscript unobtainable for review | 1 |
| After attempted author contact | |
| Failed author contact | 1 |
| Total | 1697 |
