Table 1.
Patient Demographics and Clinical Characteristicsa
| Variable | No. (%) of Patients | |
|---|---|---|
| Lactate Clearance Group (n = 150) | ScvO2 Group (n = 150) | |
| Age, mean (SD), y | 59.8 (17.6) | 61.6 (17.6) |
| Race White |
88 (59) |
77 (51) |
| Black | 47 (31) | 56 (37) |
| Sex Men |
83 (55) |
80 (53) |
| Women | 67 (45) | 70 (47) |
| Comorbidities Diabetes mellitus |
45 (30) |
57 (38) |
| Chronic obstructive pulmonary disease | 25 (17) | 25 (17) |
| Human immunodeficiency virus infection | 12 (8) | 13 (9) |
| End-stage renal disease | 15 (10) | 14 (9) |
| Active malignancy | 42 (28) | 32 (21) |
| Organ transplant | 5 (3) | 4 (6) |
| Indwelling vascular line | 6 (4) | 10 (7) |
| Nursing home resident | 28 (19) | 28 (19) |
| Disease severity SAPS II score |
44.8 (18.4) |
44.1 (17.3) |
| SOFA score | 6.7 (3.6) | 6.6 (3.5) |
| MEDS score | 10.9 (3.9) | 10.6 (3.4) |
| Suspected source of infection Pulmonary |
48 (32) |
54 (36) |
| Urinary tract | 40 (27) | 39 (26) |
| Intra-abdominal | 34 (23) | 24 (16) |
| Skin/soft tissue | 19 (13) | 23 (15) |
| Blood | 8 (5) | 9 (6) |
| Unknown | 13 (9) | 9 (6) |
| Features of sepsis Lactate ≥4 |
61 (41) |
56 (37) |
| Shockb | 121 (81) | 123 (82) |
| Culture positive | 123 (82) | 127 (85) |
| Blood culture positive | 62 (41) | 53 (35) |
| Gram positive | 33 (22) | 36 (24) |
| Gram negative | 29 (19) | 17 (11) |
Abbreviations: MEDS, mortality in emergency department sepsis; SAPS, Simplified Acute Physiology Score; ScvO2, central venous oxygen saturation; SOFA, Sequential Organ Failure Assessment.
a
Continuous data are compared using an unpaired t test; categorical data, using the χ2 test.
b
Shock is defined as a systolic blood pressure of 90 mm Hg or less after receiving a 20 mL/kg-fluid bolus.