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. Author manuscript; available in PMC: 2011 Jun 26.
Published in final edited form as: Tetrahedron. 2010 Jun 26;66(26):4745–4759. doi: 10.1016/j.tet.2010.03.093

Scheme 5a.

Scheme 5a

aConditions: (a) TIPSCl, imidazole, DMF, 90 °C, 10 h, 89%; (b) t-BuLi, THF, −78 °C to 0 °C; then ICH2CH2I, −78 °C to rt, >93%; (c) TBAF, THF, rt, 30 min, 96%; (d) MeI, NaH, THF, 92%; (e) n-BuLi, THF, −78 °C; then Me2SiHCl, −78 °C to rt, 71%; (f) [RuCl2(p-cymene)]2 (2 mol %) CH3CN-H2O, rt, 1 h, 81%.