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The NAD de novo biosynthesis pathway. l-Aspartate is converted to nicotinate mononucleotide through the three reactions catalyzed by l-aspartate oxidase, encoded by nadB, quinolinate synthetase, encoded by nadA, and quinolinate phosphoribosyltransferase, encoded by nadC. Nicotinate mononucleotide, which is also generated from nicotinate, is subsequently converted to NAD. PRPP, 5-phosphoribosyl-1-pyrophosphate; PPi, inorganic pyrophosphate.
